I think how one live's one's life relative to social interaction vs invasive procedures (vaccinations) are two very separate discussions and not necessarily inclusive.
When a vaccination for COVID-19 is proven safe and available, I will be in line to get my shot. I think to actively participate in society one should vaccinate to prevent the spread of life threatening diseases.
However, absent of such a vaccination, I simply refuse to live a sheltered life simply because elected pols or pol appointed scientists and/or healthcare workers makes such a proclamation. Look no further than Michigan for hypocrisy in such proclamations. All private construction projects were halted, but, all government projects were allowed to proceed. Why is the risk of infection for workers warranted for state government construction projects and not for private concerns?
Since 9/11, the US as spun 180 degrees (again) on its philosophical axis pertaining to how government interacts in our daily lives. By that I mean, WE (citizens of the US) still believed in self-determination principles. After 9/11, many citizens and pols turned to the federal government for protection in our daily lives from unforeseen dangers and we see that even more so today.
Prior to 9/11, we had FDR's New Deal legislative packages of 1933 and 1936 where once self-reliant folks turned to DC for hope and answers.
The Supremacy clause (for the federal government) has always been embedded in Article VI Paragraph 2 of the Constitution. Yet, it wasn't until McCulloch v. Maryland (1819) in which SCOTUS first affirmed the federal government's supreme power over the states in certain matters. And DC has been chipping away at States Rights (which many argue are individual rights as well) such ever since.
Today, pols are about political power and the ability to project that power and will onto the populace. And this projection of power cuts across the political spectrum; no one party or caucus has a monopoly on the accumulation of and projection of that power.
The time proven concept of piecemeal, political compromise exhibited by President Reagan and Speaker O'Neill to pass economic legislation benefiting most Americans seems like ancient history. And even though we've experienced some serious bumps in the economic road since the 80's, we are still enjoying an economy directly benefiting from the legislation hammered out by those two great Americans.
If you look too DC or your state capital for answers to protect yourself and loved ones or enhance your daily life, I think you will be left standing along the side of the road with an empty cup in hand.
Stay safe and enjoy Life, you only have one!