During the 1700s Yellow Fever was an annual event. In the 1780s there were very severe outbreaks, severe enough to almost wipe out our founding fathers.
I found this article fascinating, especially some of the parallels occuring today.. Here are some of the takeaways:
Black doctors saved America’s founding fathers from the virus
Hamilton was a wimp.
Hospitals were only for the indigent.
Miracle cures were first fostered by doctors and then promoted without evidence by desperate politicians.
Social intercourse was forbidden