I've been playing this game since I picked it up from the early launch Thursday night. I just finished Spider-Man just the day before and I must say coming from that, it's a whole lot of different experience.
Spider-man is fast paced and efficient, with fast travel and stuff. The game is easily finished within a few days.
Red Dead Redemption II though... it's a whole different beast. So much realism in this game. There's no fast travel until a certain point of the game, and even then, it's still pretty limited. There's fall damage, and you need to be careful with your actions, or there will be consequences. If your horse die before you can cure it, then it's gone forever.
But man, is this game slow paced or what? I'm not saying this a bad way of course. Playing this game reminds me a lot of Zelda - Breath of the Wild. The fun part playing it is to explore. Ignore the main mission for a while. Go venture with your horse, help out strangers on the road, hunt some animals, buy yourself some new clothes. Heck, go get a haircut and take a warm bath.
It's a game that needs to be consumed slowly. But man, does it feel satisfying.