Microsoft used to rule the desktop and browser markets. Got disrupted organically. IBM before them.
Both Microsoft and IBM were subject to major antitrust actions in the US and EU and were forced to change their business practices as a result. Not sure what you mean by 'organically.'
As for Google, the EU has fined them billions over Android, Google Shopping and Ad-Sense antitrust violations, though some of those judgments are still under appeal.