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    • My parents are both very math and science-minded. My dad was a mechanical engineer and my mom developed science curricula for primary school, founded a math and science camp, and has a very scientific approach to how she operates in the world (in everything from the quilts she designs to the courses in robotics and lego-logo she created for elementary school kids). It was really influential having parents that were creators and inventors, and who didn't shy away from challenging math. At the same time, I think my mom is still a little disappointed that I didn't become an opera singer ;)

      I was probably around ten years old, and I'm not sure who said it to me... but you know how it's really common for people for people to demur about math? Saying things like, "Oh, I'm TERRIBLE at math!" almost with a bit of pride in their voice? When I was a kid, someone pointed out how weird that is! How even though math intuition is just as intrinsic to the adult human brain as reading (think about the subconscious calculations your brain is doing just to know when and how hard to start breaking to stop your car at a stop light) no one would ever say, "Oh, I can't READ! I SUCK at READING!"

      It put it in my brain early that the notion that it is somehow cool to suck at math is a weird (dumb) cultural phenomenon; I think I still cringe a little when someone brags about being bad at math.

    • Long reads are going to be awesome for robusting detecting structural variants and copy number polymorphisms! Right now these can be hard to detect with short read sequence data and as a result there is a whole class of variants whose effect on human health we are doing a poor job of detecting.